Wed 5 Nov, 2008

Postsynaptic PKA in homosynaptic LTD

Comments (0) Filed under: Molecular & Cellular Neuroscience
Posted by andrew

Kameyama et al
Neuron 21, 1163-1175, Nov 1998

* NMDA-dependent LTD is associated with Ser845 dephosphorylation
* that Ser845 is normally phosphorylated by PKA
* dephophorylation of postsynaptic PKA substrate is crucial for LTD expression
* injection of cAMP analog: soaks up the PKA and prevents LTD induction!
* PKA inhibitor: produces synaptic depression that occludes homosynaptic LTD
* dephosphorylation of PKA site is one mechanism for NMDAR-dependent homosynaptic LTD expression

Wed 5 Nov, 2008

NMDA induces LTD and GluR1 dephosphorylation

Comments (0) Filed under: Molecular & Cellular Neuroscience
Posted by andrew

Lee at al.
Neuron, 21, 1151-62, Nov 1998

* brief bath application of NMDA to hippocampal slices produces LTD
* LTD is in the CA1 region of the hippocampus
* five properties: sensitive to age, saturable, postsynaptic, reversble, doesn’t change PPF
* chemLTD and homosynaptic LTD are mutually occluding
* common expression mechanism of LTD?
* PSSA: phosphorylation site specific antibodies
* induction of chemLTD induces persistent dephosphorylation of Ser845, but not Ser831
* unexpected role of PKA in postsynaptic modulation of excitatory synaptic transmission.