Mon 27 Oct, 2008
2004 review of plasticity in Neuron 44, 30 Sept by Malenka and Bear.
* LTP and LTD play what functional roles in specific types of experience-dependent plasticity?
* clear that there are many forms of LTP and LTD and they share some but not all of the properties of NMDAR dependent LTP and LTD
* the question of whether LTP and LTD are used for memory is pretty much a moot point now
*mossy fiber LTP appears to be PKA-dependent, presynaptic in origin, and leads to an increased Pr (probability of neurotransmitter release). All presynaptic, as opposed to the postsynaptic NMDAR-dependent LTP
* NMDAR-dependent LTD: induced by low frequency stimulation
* requires actiation of a serine-threonine phosphatase cascade
* most of the work has been done in CA1
* mGluR-depenent LTD: can also be induced by long periods of 1 Hz pulses
* inhibition of NMDARs blocks LTD, actiation of NMDARs induces it
* one synaptic protein that appears to be a slot protein is PSD-95
* NmDAR activation leads to ubiquitination and degradation of PSD-95 - might act for LTD and to remove synapses (Mike Ehlers type of stuff)
* retrograde signaling by endogenous cannabinoids coincides with activation of presynaptic NMDARs?
