Mon 27 Oct, 2008
Nicoll & Malenka, Nature, vol 377, 14 Sept 1995
Key concepts:
* two forms of LTP: NMDAR-dependent and mossy fiber LTP
* NMDAR dependent: relies on rise in postsynaptic calcium levels
* mossy fiber type: independent of NMDARs, requires a rise in presynaptic Ca2+
* mossy fiber LTP is accepted to be expressed presynaptically
* what about site of expression of NMDAR-dependent LTP? Still controversial
* evidence favors postsynaptic for NMDAR-dep, and there’s lots of studies on retrograde messengers that can pass from the postsynapse to presynapse and induce presynaptic changes
